Abstract
Consideration of facial muscle dynamics is underappreciated among clinicians who provide injectable filler treatment. Injectable fillers are customarily used to fill static wrinkles, folds, and localized areas of volume loss, whereas neuromodulators are used to address excessive muscle movement. However, a more comprehensive understanding of the role of muscle function in facial appearance, taking into account biomechanical concepts such as the balance of activity among synergistic and antagonistic muscle groups, is critical to restoring facial appearance to that of a typical youthful individual with facial esthetic treatments. Failure to fully understand the effects of loss of support (due to aging or congenital structural deficiency) on muscle stability and interaction can result in inadequate or inappropriate treatment, producing an unnatural appearance. This article outlines these concepts to provide an innovative framework for an understanding of the role of muscle movement on facial appearance and presents cases that illustrate how modulation of muscle movement with injectable fillers can address structural deficiencies, rebalance abnormal muscle activity, and restore facial appearance.
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Introduction
Theories of facial aging have largely focused on changes in skin, underlying fat, and bone that result in sagging and folds [1], while the role of muscle in aging has generally been neglected [2]. The complementary and distinct ways in which injectable fillers and neuromodulators have generally been used for rejuvenation and improvement of facial esthetics [3] illustrate how skin and fat are considered separately from muscle action. Injectable fillers are customarily used to fill static wrinkles, folds, and localized areas of volume loss [4,5,6,7]. Neuromodulators (such as onabotulinumtoxinA) are used to reduce muscle movement in overacting muscles, for example, to diminish hyperdynamic lines or correct position or asymmetry by reducing muscle activity [8,9,10,11,12,13]. However, long-term observations of patients with certain structural deficiencies treated only with injectable fillers suggest that fillers can also be used to alter muscle movement (myomodulation) in facial esthetic treatments and may provide another tool, in addition to neurotoxins, in the armamentarium of facial muscle modulation.
In the facial literature, consideration of the role of functional muscle groups, including synergists and agonist/antagonist pairs, is focused on the opposing actions of brow levators and depressors, which has guided clinical practice [14, 15]. However, it is clear that functional muscle groups contribute to facial movement and appearance, not just in the example of the brow, but throughout the face. Structural deficiency in either bone or fat pads can precipitate abnormal movement patterns, and such an imbalance, whether resulting from congenital structural deficiencies or changes in muscle action with aging, is reflected in both movement and appearance. The aim of this article is to introduce the concept of using injectable filler treatment to modulate facial muscle action and to present cases that illustrate the use of this approach. Filler treatment can be used to address muscle imbalance that results from structural defects with or without volume loss, and therefore, cases without substantial volume loss were selected to illustrate this approach.
Understanding Muscle Movement in the Face
Mimetic muscles have several characteristics that differentiate them from skeletal muscles. Generally, mimetic muscles have their origin in bone and insert on the skin and among the fibers of other muscles, with no tendons, except for the sphincteric muscles [16]. In addition, mimetic muscles appear to lack typical muscle spindles [17, 18], which function in resetting resting tone. Together with these characteristics, three key aspects underlie the role of muscle movement in facial expression: length–tension relationship, muscle pulley and lever systems, and the action of functional muscle groups.
Length–Tension Relationship
The force that a muscle produces is described in part by the length–tension relationship, which relates to two components in a muscle model: a contractile component (active tension, produced by contraction of the muscle) and an elastic component (passive tension, resulting from the elasticity of associated tendon and connective tissues). Peak force is produced by the contractile component of the muscle at resting length and is reduced if the muscle fiber is either shortened or stretched. Passive tension increases with increasing length in the elastic component: As the connective tissue associated with the muscle is pulled, it resists and pulls back when released.
For mimetic muscles that have no tendons and insert in the skin [16], the elasticity of the skin and connective tissue is the primary source of the elastic component of the length–tension relationship. Loss of skin elasticity in aging thus alters the length–tension relationship for mimetic muscles: The muscle’s ability to return to rest after contraction and to maintain the resting position of the skin is diminished. Moreover, loss of elasticity, together with the decrease in fat compartment and bone bulk, leads to sagging of the skin [19], which further stretches the facial muscle in a domino effect.
Muscle Pulley and Lever Systems
Biomechanical fixed pulley systems alter the angle of action of muscles, and levers increase their mechanical advantage, enhancing muscle force or displacement [20, 21]. An example of such a biomechanical system in the body is the patella [20]. The lateral suborbicularis oculi fat pad (SOOF), located at the lateral/inferior orbital rim and deep to the orbicularis oculi and zygomaticus major [22, 23], acts as a pulley glide plane [1] and, together with bone, as a lever fulcrum for the zygomaticus major muscle. Acting over the SOOF appears to provide a mechanical advantage to the zygomaticus major, which lifts the corners of the mouth in a smile. In aging, the loss of structure beneath the muscle, either from loss of bone or the loss and/or ptosis of fat, might decrease that fulcrum effect, reducing the muscle’s force and diminishing its ability to lift the corner of the mouth.
Functional Muscle Groups
Groups of muscles (agonists and antagonists) working in harmony contribute to a normal, youthful appearance in facial expression. Levators and depressors work in opposition, and their interactions underlie facial appearance at rest and in dynamic expression. In youth, levators are usually stronger than depressors [24, 25]. The levator muscle’s ability to maintain the position of soft tissue structures of the face is counteracted by the downward pull of gravity and the pull of its depressor antagonists. However, the balance between antagonist muscles may be disrupted, due to structural deficiencies in youth or due to bone and/or soft tissue loss in aging: If a levator muscle lacks or loses lifting power, the depressor is freed to act with reduced opposition.
Consider the synergistic levators of the upper lip: In youth, the zygomaticus major and minor muscles play a critical role in making the corner of the mouth tilt up in a smile. If the zygomaticus major has reduced lifting power due to a lack of underlying structural support, the relative role of the risorius muscle increases and produces a more horizontal smile. If zygomaticus major lifting capacity is further diminished, the depressor anguli oris (DAO) muscle predominates, and a “DAO smile,” with the corners of the mouth downturned, is observed [11, 26]. The lack of underlying structure leading to DAO smile may result from changes over time in aging, or it may occur in youth due to structural deficiency.
Addressing Muscle Movement with Injectable Fillers
Each of these biomechanical concepts contributes to our understanding of changes in muscle movement during aging, as well as in cases of facial palsy. In the typical youthful face, there is a clear convexity of the upper cheek due to intact zygomatic arch, malar fat, and SOOF. Under these ideal conditions there is optimal pulling force of the zygomaticus major muscle. In aging, midface volume loss, displacement of fat pads, and loss of skin elasticity may alter zygomaticus major muscle action. The distance between the zygomaticus major origin in the zygomatic bone and insertion in the modiolus area at the corner of the mouth [27] increases when skin sags due to deflation of fat pads, and as a result, the corner of the mouth falls (Fig. 1). The stretching of the fibers of the zygomaticus major results in a loss of resting tension and power in contraction. At the same time, any mechanical advantage of the lever effect over the lateral SOOF is reduced as SOOF volume is depleted. Consequently, the zygomaticus major can no longer adequately counterbalance the downward gravitational pull and the contracting force of the DAO [11, 26].
Case 1, a mature woman with an asymmetrical smile, illustrates some of these effects (Fig. 2). On her right side, she presents a zygomatic smile, but on her left she shows a DAO pattern (Fig. 2c, left). Before treatment, her left cheek sags, yielding a more prominent nasolabial fold. The zygomaticus major is less efficient on her left side, and the balance between weakened zygomaticus major and its antagonist, DAO, has been lost. DAO is now free to pull down the corner of the mouth.
The presence of fillers can act mechanically to alter muscle movement by either facilitating their action, via a lever or pulley effect, or decreasing contracting by blocking their movement (Table 1). A bolus of filler injected under (deep to) a muscle increases its convexity, acting as a fulcrum to increase mechanical advantage. Conversely, injecting filler more superficially may reduce contraction by impeding muscle movement. These are simple mechanical effects.
The Case 1 patient was treated on both sides with Juvéderm Voluma® (Allergan plc, Dublin, Ireland). On her right side, a bolus was injected at the level of the bone on the zygomatic arch under zygomaticus major. On her left side, two boluses were injected at the same plane (Fig. 2b). The structural support increased the muscle’s lifting action, and mechanical advantage on her left side was enhanced. Voluma was injected superficial to mentalis, depressor labii inferioris, and DAO along the labiomental angle on her left side only. This mechanical obstacle to DAO movement decreases its downward pulling effect. After treatment (Fig. 2c, right), the action of zygomaticus major is facilitated on both sides and DAO is blocked on her left, so that zygomaticus major now lifts that corner of her mouth.
A lack of structural support due to bone deficiency can result in abnormal muscular contraction and surface deformation. Case 2 (Fig. 3) illustrates the contribution of a deficiency of the anterior nasal spine and premaxilla to gummy smile, and correction using injectable filler treatment. The young Asian patient presented with a lack of projection of the anterior nasal spine, retruded underdeveloped columella, and a deficit in the projection of the upper maxilla. The lack of structural and mechanical support results in excessive movement of the upper lip levators (levator labii superioris alaeque nasi [LLSAN], levator labii superioris, and zygomaticus minor), which produces gummy smile (Fig. 3c, left). The lack of support also leads to collapse of the tip of the nose and widening of the nasal flare. Voluma injected along the premaxilla and at the projection of the anterior nasal spine helped to compensate for the bone deficiency. After treatment, there is a reduction in the movement of the upper lip levators during smile and the upward retraction of the upper lip is decreased (Fig. 3c, center and right panels). Injection behind the columella has also helped to stabilize the nose.
The third case (Fig. 4) is a young woman who has no apparent deficiency at rest (Fig. 4c). However, on animation, a lack of proper bone support in her chin becomes evident (Fig. 4d, left). When she pouts, mentalis is activated and over-contracts. This results in upward rotation of her chin and protrusion of the lower lip, with excessive skin wrinkling and deformation. After treatment with Voluma, the patient’s pout is normal (Fig. 4d, right). The presence of a mechanical barrier at the labiomental angle and chin apex prevents the upward rotation and consequent skin wrinkling. Note that the extreme over-contraction of mentalis is blocked while preserving proper mentalis action and therefore, the patient is still able to protrude the lower lip. When over-contraction of mentalis is treated with onabotulinumtoxinA, the ability to evert the lower lip can be reduced or lost depending on the dose.
In a second young woman with a lack of bone support for mentalis (Case 4; Fig. 5), distortion of the chin is evident both at rest (Fig. 5c, left) and when she purses her lips (Fig. 5d, left). Immediately after treatment, improvement in her chin is observed at rest (Fig. 5c, left center) and on animation (Fig. 5d, left center). Blocking the excessive movement of mentalis eliminates the resulting distortion and allows the patient to purse her lips with no skin wrinkling.
Case 5 (Fig. 6) is a young woman with notable distortion on animation (kissing, pouting). Normally, movement of the upper and lower lips during pursing is governed by nose and chin position, due to stability at the nasolabial angle and the labiomental angle, respectively. With support at these two sites, the direction of movement in a kiss is horizontal. The patient presented here lacks support at the level of the labiomental angle and chin. Instability at the labiomental angle perturbs the contraction of orbicularis oris. When she is asked to purse her lips (kiss; Fig. 6c, left), this instability causes both upper and lower lips to drop down, resulting in distortion. The normal action of mentalis in pouting leads to protrusion of the lower lip. In this case, however, the patient cannot properly protrude the lip when asked to pout (Fig. 6d, left). Instead, her lower lip everts toward the oral cavity and hides the upper lip. Treatment with Voluma in the chin and Juvéderm® Ultra Plus injectable gel (Allergan plc) in the lip border allows the patient to produce a natural appearance in a kiss (Fig. 6c, right) and pout (Fig. 6d, right). With support in the soft tissue of chin and lips, mentalis and orbicularis oris contract in a more balanced, stable, and organized way. The chin and lower lip are improved by support to mentalis in the labiomental angle and chin apex. The upper lip is improved both directly by Juvéderm Ultra Plus injection and indirectly by the more organized contraction in the lower lip.
The sixth case is a man with mild facial asymmetry, but normal facial nerve function observed at rest and on animation (Fig. 7). At rest, there is a more prominent nasolabial fold on his left side due to contraction of LLSAN, and his upper lip is slightly elevated (Fig. 7c, left). Upon animation, both LLSAN and levator labii superioris are over-contracted (Fig. 7d, left), and he presents lower teeth show on his left side when smiling. The patient was injected with two filler boluses under zygomaticus major at the level of his zygomatic arch and zygomatic eminence, respectively (Fig. 7b). He was also injected at the labiomental angle on both sides, and at the chin apex. After treatment, there is less lateral recruitment of the LLSAN and the improvement of nasolabial fold can be observed at rest (Fig. 7c, right). On animation, the upper lip is now better aligned, and as observed in his oblique view, he presents a stronger zygomatic smile due to facilitation of the zygomaticus major muscle via the fulcrum effect (Fig. 7d, right). He also presents less lower teeth show.
The final case provides a most compelling demonstration of the use of injectable fillers for myomodulation. Case 7 (Fig. 8) is a middle-aged man with facial palsy on the right side resulting from acoustic neuroma surgery in 2011. Prior to injectable filler injection, no treatment to improve the facial asymmetry was performed. Before treatment (Fig. 8c, left), the patient had classic signs of facial palsy on his right side: a lack of function of orbicularis oculi and zygomaticus major, with scleral show and skin laxity. A more prominent nasolabial fold and lip deviation toward his left side is observed. The patient’s smile (Fig. 8d, left) shows even greater deviation of the oral commissure toward his hyperkinetic side (left). On his facial palsy side (right), the contraction of lateral platysmal band shows that the facial nerve is not completely damaged. Slight contraction of the zygomaticus major, indicated by the presence of a dynamic line at the modiolus level and worsening of the skin excess at the lower eyelid, suggests that there is residual activity in the zygomatic branch. When the patient tries to close his eyes tightly (Fig. 8e, left), abnormal coordination of facial muscles is demonstrated by his frown, excessive contraction of platysma, and activation of orbicularis oris on his left with the eyebrow elevated. When he tries to close his eyes without frowning (Fig. 8f, left), scleral show and abnormal behavior of lateral muscles are observed.
Mimetic muscles on both sides were treated with filler injections (Fig. 8b), with depth of injection the major difference between the two sides. The treatment of the patient’s right side focused on lifting the cheek and stabilizing the lips. Filler was injected deep to muscle fibers, at the level of the bone wherever possible, to create a lever effect to increase muscle movement. On his left (hyperkinetic) side, fillers were injected superficial to the muscle, at the subcutaneous level, in order to reduce contraction by providing a mechanical obstacle to muscle contraction. Filler products and volumes used in this case are shown by injection site in Table 2. Topographical muscle anatomy and mimetic animation assessment during the injection were used to guide the treatment. There was no need for the use of electromyography.
Immediately after the injections, better symmetry and muscle coordination were observed. On smiling, there is a reduction in the upper lateral excursion of the zygomatic major muscle on his left side and better positioning of the oral commissure and upper and lower lips (Fig. 8d, immediately after). When closing his eyes (with effort) immediately after treatment, a deeper nasolabial fold is apparent on his left, indicating a change in muscle behavior between his right and his left side (Fig. 8e, immediately after). When he tries to close his eyes without effort, there is improvement in scleral show immediately after treatment (Fig. 8f, immediately after).
Over the 6 months following treatment, the patient was instructed to practice closing his eyes and smiling more symmetrically using a mirror. Although improvement resulting directly from filler treatment is evident in the patient’s smile and eye closure in the photographs taken immediately after treatment (Fig. 8d–f), the symmetry of his smile continues to improve progressively with exercise (Fig. 8d, 1–6 months). One month after treatment, contraction of zygomatic muscles on his right side appears enhanced and there is less recruitment of platysma (Fig. 8d, 1 month). By 4 months after treatment, contraction of orbicularis oculi and position of the eyebrows are improved (Fig. 8e, 4 months), the patient closes his eye more naturally, and enhanced zygomatic action is observed (Fig. 8f, 4 months). At 6 months, he closes his eyes effortlessly without recruitment of adjacent muscles (Fig. 8e and f, 6 months).
Summary and Conclusions
Deficits in facial structure can yield abnormal muscle action reflected at the skin and across the face. When structural support is absent or lost, muscle action is altered, affecting the balance in activity between muscles. Examining the interactions between facial structure and muscle movement—and recognizing unbalanced action in muscle synergists and antagonists—allows the clinician to understand the effects on appearance both at rest and on animation. The cases presented here provide support for the use of myomodulation, addressing muscle movement with injectable fillers in the treatment of facial structural deficiencies. Injectable filler treatment can be used to support muscle movement or block overaction regardless of whether the imbalance is due to a structural deficiency or a loss of volume in aging, and indeed, the clinician does not need to isolate the contribution of these factors to an imbalance in order to use fillers to treat it.
The injection details outlined in the cases presented here are provided as an overview of how myomodulation with fillers can be used, and not as a guide to treatment. Further investigation examining specific uses for this approach will be needed in order to present techniques for the administration of injectable fillers for treating particular deficiencies. In addition, future studies using electromyography to measure changes in muscle activity before and after treatment, together with videography to closely compare appearance on animation, will be needed to confirm hypotheses about changes in muscle activity underlying observed esthetic effects and improvement in palsy patients.
The framework presented here is based on experience treating patients with facial palsy, structural deficits, and effects of aging. The cases included are young and middle-aged individuals treated for effects that likely result, at least in part, from structural deficiencies. Based on an understanding of the importance of structure and stability in muscle function, experience with cases such as these suggests that where structure is lacking, myomodulation with fillers should be considered before neurotoxin injection. Filler treatment can be used to correct structural deficiency, support muscles to facilitate their action, and provide an obstacle to extreme muscle excursion and depressor contraction. Neurotoxins, to be sure, are a powerful tool of primary importance for modulating facial muscle activity. However, injectable fillers have a unique and important role to play, in that they can both support weak muscle action and locally block overacting muscles. When used together with fillers, toxins may perform more effectively in blocking over-contracting depressors and fine-tuning the balance of activity among synergist and antagonist muscle groups. Using these tools together, the clinician can reestablish natural structural conditions and rebalance muscle movement to restore facial appearance to that of a typical youthful individual.
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Funding
This review was sponsored by Allergan plc, Dublin, Ireland. Writing and editorial assistance was provided to the author by Kathleen M. Dorries, PhD, of Peloton Advantage, Parsippany, NJ, and was funded by Allergan plc. Neither honoraria nor other form of payments was made for authorship.
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de Maio, M. Myomodulation with Injectable Fillers: An Innovative Approach to Addressing Facial Muscle Movement. Aesth Plast Surg 42, 798–814 (2018). https://doi.org/10.1007/s00266-018-1116-z
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DOI: https://doi.org/10.1007/s00266-018-1116-z